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Role of tumor cell immune escape mechanisms in cytomegalovirus‐mediated oncomodulation
Author(s) -
Cinatl Jindrich,
Scholz Martin,
Doerr Hans Wilhelm
Publication year - 2005
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20018
Subject(s) - cytomegalovirus , immune system , cell , cell mediated immunity , mechanism (biology) , biology , immunology , immune escape , tumor cells , virology , neuroscience , cancer research , virus , microbiology and biotechnology , immunity , herpesviridae , viral disease , genetics , philosophy , epistemology
Abstract It has been known for a long time that cytomegalovirus (CMV) has evolved mechanisms that allow the escape from the host immune surveillance. In the past, many efforts have been done to elucidate the molecular mechanisms underlying this virus‐mediated immune escape and thus virus persistence. However, it is unknown, whether CMV may also impair immune responses directed against tumor cells. This might have severe consequences on tumor progression and may explain the growing evidence for CMV‐mediated oncomodulation. This review summarizes recent work on CMV‐mediated immune escape mechanisms of tumor cells and oncomodulation and proposes novel aspects that may be important for understanding the CMV‐associated tumor progression. © 2004 Wiley Periodicals, Inc.