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Intracellular cargo delivery using tat peptide and derivatives
Author(s) -
Zhao Ming,
Weissleder Ralph
Publication year - 2004
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.10056
Subject(s) - intracellular , peptide , chemistry , pharmacology , microbiology and biotechnology , biology , biochemistry
Abstract Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV‐1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat‐derived cell permeating peptides in the transduction of exogenous molecules/complexes. © 2003 Wiley Periodicals, Inc. Med Res Rev, 24, No. 1, 1–12, 2004