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Structure and function of “metalloantibiotics”
Author(s) -
Ming LiJune
Publication year - 2003
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.10052
Subject(s) - antibiotics , chemistry , bacitracin , metal ions in aqueous solution , combinatorial chemistry , function (biology) , biomolecule , metal , biochemistry , biology , genetics , organic chemistry
Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin (BLM), streptonigrin (SN), and bacitracin. The coordinated metal ions in these antibiotics play an important role in maintaining proper structure and/or function of these antibiotics. Removal of the metal ions from these antibiotics can cause changes in structure and/or function of these antibiotics. Similar to the case of “metalloproteins,” these antibiotics are dubbed “metalloantibiotics” which are the title subjects of this review. Metalloantibiotics can interact with several different kinds of biomolecules, including DNA, RNA, proteins, receptors, and lipids, rendering their unique and specific bioactivities. In addition to the microbial‐originated metalloantibiotics, many metalloantibiotic derivatives and metal complexes of synthetic ligands also show antibacterial, antiviral, and anti‐neoplastic activities which are also briefly discussed to provide a broad sense of the term “metalloantibiotics.” © 2003 Wiley Periodicals, Inc. Med Res Rev, 23 No. 6, 697–762, 2003