Open AccessSERS sensing of perampanel with nanostructured arrays of gold particles produced by pulsed laser ablation in water
Author(s) -
Santoro Marco,
Fazio Enza,
Trusso Sebastiano,
Tommasini Matteo,
Lucotti Andrea,
Saija Rosalba,
Casazza Marina,
Neri Fortunato,
Ossi Paolo Maria
Publication year - 2018
Publication title -
medical devices & sensors
Language(s) - English
Resource type - Journals
ISSN - 2573-802X
DOI - 10.1002/mds3.10003
Subject(s) - materials science , fluence , ablation , perampanel , nanoparticle , nanosecond , laser ablation , laser ablation synthesis in solution , raman scattering , irradiation , laser , surface plasmon resonance , nanotechnology , raman spectroscopy , optoelectronics , optics , x ray laser , laser power scaling , medicine , physics , aerospace engineering , nuclear physics , adverse effect , engineering
Noble metal nanoparticles ( NP s) are among the most extensively studied colloidal systems, due to their surface plasmon resonances ( SPR ) of interest for biological sensing. We report here the synthesis of Au nanoparticles as water‐based colloids by nanosecond (τ = 5 ns) and picosecond (τ = 6 ps) pulsed laser ablation at the fixed fluence of 1.5 J/cm 2 (λ = 532 nm) and different irradiation times (20 minutes, ns irradiations; 5 minutes, ps irradiations). Both ns and ps ablation lead to the synthesis of highly stable and chemically pure NP s. ps pulses allow synthesizing in remarkably short times (few minutes) smaller NP s with a narrower size distribution than using ns pulses. The surface‐enhanced Raman scattering ( SERS ) activity of Au NP s produced by ps ablation was tested, obtaining the first SERS spectrum of the new generation antiepileptic drug perampanel, whose clinical interest is relevant.