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1 H Magnetic resonance spectroscopy of the lentiform nucleus in primary focal hand dystonia
Author(s) -
Naumann Markus,
WarmuthMetz Monika,
Hillerer Claudia,
Solymosi László,
Reiners Karlheinz
Publication year - 1998
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870130611
Subject(s) - dystonia , focal dystonia , basal ganglia , magnetic resonance imaging , creatine , medicine , pathology , central nervous system disease , movement disorders , neuroscience , nuclear medicine , psychology , central nervous system , radiology , disease
Several radiologic findings point toward the lentiform nucleus as a possible site of lesion in primary dystonia. Histologic examinations, however, have shown inconsistent results. 1 H‐magnetic resonance spectroscopy (MRS) has proved helpful to assess neuronal degeneration in a variety of basal ganglia disorders. MRS data of dystonia patients are, however, lacking so far. 1 H‐MRS centered on the lentiform nuclei was performed in 14 patients with primary focal hand dystonia and in 12 healthy control subjects using a 1.5‐T MR imager. No statistically significant differences of N‐acetylaspartate/creatine and lactate/creatine ratios were found between patients and control subjects. Based on these data, the authors found no evidence that primary focal dystonia was associated with a conspicuous loss of lentiform nucleus neurons or a marked disturbance of the aerobic metabolism, although minor abnormalities cannot be excluded because of the possibly limited sensitivity of the method.