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Cinnarizine‐induced parkinsonism: Ten years later
Author(s) -
MartíMassó José F.,
Poza Juan J.
Publication year - 1998
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870130313
Subject(s) - cinnarizine , parkinsonism , medicine , dyskinesia , tardive dyskinesia , drug withdrawal , pediatrics , retrospective cohort study , anesthesia , disease , surgery , parkinson's disease , psychiatry , drug , schizophrenia (object oriented programming)
A retrospective study was carried out to investigate the evolution of patients diagnosed with cinnarizineinduced parkinsonism (CIP) over the past 15 years. A total of 74 cases of CIP were found among 172 patients with druginduced parkinsonism (DIP). Both CIP and other DIP were significantly more frequent in women. No clinical differences between CIP and other DIP were found. Most of the patients (66 of 74) completely recovered after cinnarizine withdrawal in 1–16 months. Eleven patients later developed Parkinson's disease; four of them had previously recovered. Five patients had tardive dyskinesia. CIP accounts for a high proportion of DIP referred to neurologists in populations in which cinnarizine is widely prescribed. The symptoms typically resolve after drug withdrawal, although complete recovery may take more than 1 year.