Late components of the event‐related potentials and their topography in Parkinson's disease | Zendy

Lagopoulos Jim | Zendy; Clouston Paul | Zendy; Barhamali Homayoun | Zendy; Gordon Evian | Zendy; Li Waiman M. | Zendy; Lesley Julian | Zendy; Morris John G. L. | Zendy

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Late components of the event‐related potentials and their topography in Parkinson's disease

Author(s) -

Lagopoulos Jim,

Clouston Paul,

Barhamali Homayoun,

Gordon Evian,

Li Waiman M.,

Lesley Julian,

Morris John G. L.

Publication year - 1998

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.870130211

Subject(s) - parkinson's disease , disease , neuroscience , degenerative disease , event (particle physics) , psychology , central nervous system disease , medicine , physical medicine and rehabilitation , physics , pathology , quantum mechanics

Late components of the event‐related potential (ERP; N100, P200, N200, and P300) were elicited using an auditory oddball paradigm (with a button‐press response to target stimuli) in 15 Parkinson's disease (PD) patients and 50 normal control subjects. Compared with control subjects, PD subjects showed a significant decrease in N200 amplitude. Between‐group topographical differences in N200 amplitude were evident at central (C3, Cz, C4) and temporal (T5, T3, T4, T6) regions. The results may reflect a deficit in response selection in PD possibly resulting from a dysfunction associated with the abnormalities in the central and temporal regions found to have a decreased N200 amplitude compared with normal control subjects in this study.

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