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Gait disorder and parkinsonian signs in patients with stroke related to small deep infarcts and white matter lesions
Author(s) -
van Zagten Marian,
Lodder Jan,
Kessels Fons
Publication year - 1998
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870130119
Subject(s) - parkinsonism , hyperintensity , stroke (engine) , central nervous system disease , atrophy , medicine , lacunar stroke , cardiology , psychology , resting tremor , physical medicine and rehabilitation , magnetic resonance imaging , ischemic stroke , radiology , disease , ischemia , mechanical engineering , engineering
Vascular parkinsonism is thought to be a distinct parkinsonian syndrome associated with small deep infarcts and white matter lesions (WMLs). We studied the prevalence of parkinsonian features (bradykinesia, rigidity, tremor, and gait disorder) in relation to small deep or territorial infarcts and WMLs on computed tomography (CT) in 62 lacunar and 41 territorial stroke patients, at 3.0 (median) years of follow up. One or more parkinsonian signs were found in 36% of these patients; 11% clinically had parkinsonism. parkinsonian signs were found more frequently in lacunar than in territorial stroke patients: bradykinesia in 45% and 7%, rigidity in 13% and 7%, tremor in 6% and 7%, and gait disorder in 16% and 7%, respectively. Patients with WMLs at study entry (n = 16) were compared with those without WMLs (n = 87): 56% and 25% had bradykinesia, 25% and 8% rigidity, 25% and 3% tremor, and 38% and 8% gait disorder, respectively. Regression analysis with adjusted odds ratios ([a]OR) showed that WMLs at study entry were associated with bradykinesia ([a]OR 8.0, 95% confidence interval [CI] 1.6‐41.6), gait disorder ([a]OR 7.1, 95% CI 1.5‐33.7), and tremor ([a]OR 7.0, 95% CI 1.2‐40.3). Bradykinesia was associated with lacunar stroke at study entry ([a]OR 11.5, 95% CI 2.4‐54.9). Thus, one third of our storke patients had one or more parkinsonian signs, and 10% clinically had a parkinsonian syndrome that differed from Lewy body parkinsonism: infrequent resting tremor, but frequent gait disorder. Parkinsonian signs were associated with WMLs and lacunar storke. Therefore, this study favors a distinct vascular parkinsonian syndrome.