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Depression in classic versus akinetic‐rigid Parkinson's disease
Author(s) -
Starkstein Sergio E.,
Petracca Gustavo,
Chemerinski Erán,
Tesón Alejandra,
Sabe Liliana,
Merello Marcelo,
Leiguarda Ramón
Publication year - 1998
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870130109
Subject(s) - depression (economics) , parkinson's disease , psychology , akinetic mutism , disease , medicine , cardiology , anesthesia , economics , macroeconomics
We examined the prevalence of major depression and dysthymia in 78 patients with the classic variant of Parkinson's disease (PD) (that is, tremor plus rigidity and/or bradykinesia), and in 34 patients with the akinetic‐rigid variant. Although the prevalence of dysthymia was similar in both groups (classic PD, 31%; and akinetic‐rigid PD, 32%), patients with akinetic‐rigid PD had a significantly higher prevalence of major depression (38% versus 15%, respectively; p < 0.01). A stepwise regression analysis demonstrated that bradykinesia was the extrapyramidal sign with the highest correlation with Hamilton depression scale scores. Our findings demonstrate a significant association between major depression and the akinetic‐rigid type of PD.