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Proton magnetic resonance spectroscopy in steele‐richardson‐olszewski syndrome
Author(s) -
Davie Charles A.,
Barker Gareth J.,
Machado Christine,
Miller David H.,
Lees Andrew J.
Publication year - 1997
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870120525
Subject(s) - globus pallidus , magnetic resonance imaging , nuclear magnetic resonance , creatine , nuclear magnetic resonance spectroscopy , proton magnetic resonance , medicine , nuclear medicine , chemistry , pathology , basal ganglia , central nervous system , radiology , physics
Proton magnetic resonance spectroscopy, localized to the lentiform nucleus, was carried out in nine patients with a clinical diagnosis of Steele‐Richardson‐Olszewski syndrome (SRO) and in eight healthy age‐matched controls. Three of the nine SRO patients had a so‐called “eye of the tiger sign” with high signal in the globus pallidus surrounded by a ring of low signal on T2 weighted magnetic resonance imaging previously only reported in Hallervorden‐Spatz disease. One of these patients had pathologically proven SRO at postmortem. The SRO group showed a significant reduction in the median concentration from N ‐acetyl groups (median, 6.87 m M ; range, 4.92–10.59 m M ; p < 0.015) compared with the control group (median, 9.85 m M ; range, 9.26–11.0 m M ). The N ‐acetylaspartate concentration was significantly reduced in seven of the nine patients studied. The reduction of the N ‐acetylaspartate‐creatine ratio from the lentiform nucleus in the SRO group may reflect neuronal loss, occurring predominantly in the globus pallidus. Proton magnetic resonance spectroscopy may be a useful, noninvasive technique to help differentiate the various parkinsonian syndromes.