Premium
G/A 1947 polymorphism in catechol‐ O ‐methyltransferase (COMT) gene in Parkinson's disease
Author(s) -
Xie T.,
Ho S. L.,
Li L. S. W.,
Ma O. C. K.
Publication year - 1997
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870120325
Subject(s) - catechol o methyl transferase , thermostability , polymorphism (computer science) , parkinson's disease , valine , allele , genetics , exon , genotype , gene , disease , biology , medicine , enzyme , biochemistry , amino acid
Abstract High and low catechol‐ O ‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine 108 polymorphism associated with polymorphic G/A 1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.