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A controlled trial of remacemide hydrochloride in Huntington's disease
Author(s) -
Kieburtz Karl,
Feigin Andrew,
McDermott Michael,
Como Peter,
Abwender David,
Zimmerman Carol,
Hickey Charlyne,
Orme Constance,
Claude Kathy,
Sotack Jennie,
Greenamyre J. Timothy,
Dunn Cynthia,
Shoulson Ira
Publication year - 1996
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870110310
Subject(s) - huntington's disease , medicine , hydrochloride , degenerative disease , pharmacology , central nervous system disease , disease , chemistry , organic chemistry
We conducted a randomized, double‐blind, placebo‐controlled tolerability study of a N‐methyl‐D‐aspartate (NMDA) glutamate receptor ion‐channel blocker, remacemide hydrochloride, in 31 independently ambulatory patients (18 men, 13 women) with Huntington's disease (HD). Subjects were randomized to receive either placebo or active remacemide at dosages of 200 mg/day or 600 mg/day. The primary outcome measure was the proportion of subjects able to compleate the study with the assigned treatment. Remacemide was generally well tolerated, and no significant differences between the treatment arms were found in the primary outcome measure. A trend toward impovement in chorea was observed among subjects administered remacemide 200 mg/day. Based on the tolerability and safety demonstrated during this short‐trem trial, remacemide warrants more extended controlled investigation in patients with HD.