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Levodopa stability in solution: Time course, environmental effects, and practical recommendations for clinical use
Author(s) -
Pappert Eric J.,
Buhrfiend Colleen,
Lipton Jack W.,
Carvey Paul M.,
Stebbins Glenn T.,
Goetz Christopher G.
Publication year - 1996
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870110106
Subject(s) - carbidopa , levodopa , chemistry , darkness , stability (learning theory) , zoology , medicine , biology , botany , parkinson's disease , computer science , disease , machine learning
We defined the temporal stability characteristics of levodopa/carbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LD/CD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.