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Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion: Preliminary findings
Author(s) -
Maricle Robert A.,
Nutt John G.,
Carter Julie H.
Publication year - 1995
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870100316
Subject(s) - levodopa , anxiety , mood , psychology , parkinson's disease , clinical psychology , psychiatry , disease , medicine
Pilot data on mood and anxiety changes in 15 Parkinson's disease patients with motor fluctuations are described based on ratings every 30 min for 5 h bracketing a 2‐h constant‐rate levodopa infusion. Robust mood and anxiety effects slightly preceded but temporally paralleled fluctuations in motor tapping scores. Research nurse ratings blind to patient ratings corroborated the changes. The magnitude of changes in mood and anxiety scores did not correlate with the magnitude of changes in tapping scores. The findings of this uncontrolled study suggest mood and anxiety fluctuations may be a common and potentially important component of levodopa‐induced fluctuation.