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n‐Hexane‐induced parkinsonism: Pathogenetic hypotheses
Author(s) -
Pezzoli G.,
Antonini A.,
Barbieri S.,
Canesi M.,
Perbellini L.,
Zecchinelli A.,
Mariani C. B.,
Bonetti A.,
Leenders K. L.
Publication year - 1995
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870100308
Subject(s) - parkinsonism , hexane , positron emission tomography , parkinson's disease , dopaminergic , medicine , chemistry , endocrinology , neuroscience , disease , psychology , dopamine , organic chemistry
n‐Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by‐products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n‐hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.