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Functional decline in Huntington's disease
Author(s) -
Feigin Andrew,
Kieburtz Karl,
Bordwell Kathy,
Como Peter,
Steinberg Kimberly,
Sotack Jenny,
Zimmerman Carol,
Hickey Charlyne,
Orme Constance,
Shoulson Ira
Publication year - 1995
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870100213
Subject(s) - chorea , dystonia , huntington's disease , rating scale , medicine , disease , severity of illness , psychology , pediatrics , physical therapy , physical medicine and rehabilitation , psychiatry , developmental psychology
We prospectively evaluated 129 patients with manifest Huntington's disease (HD) to determine the rate of illness progression and the clinical features that correlate with functional decline. A single examiner evaluated each patient using the HD Functional Capacity Scale. Standardized motor performance was also assessed in 94 of the patients (73%) using the HD Rating Scale. Total Functional Capacity declined at a rate of 0.63 ± 0.75 U per year. As functional capacity worsened, chorea lessened, and dystonia intensified. There was no correlation between rate of functional decline and age at onset of HD, body weight, gender of affected parent, or history of neuroleptic use.