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Intrathecal immune activation in three patients with progressive myoclonic ataxia
Author(s) -
Salmaggi A.,
Carella F.,
Ciano C.,
Binelli S.,
Giovannini P.,
Palazzini E.,
Girotti F.
Publication year - 1995
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870100212
Subject(s) - intrathecal , ataxia , medicine , central nervous system disease , neurological disorder , neuroscience , psychology , anesthesia
Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2‐ to 5‐year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune‐mediated damage within the central nervous system in this condition.