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Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report
Author(s) -
Jendroska Klaus,
Rossor Martin N.,
Mathias Christopher J.,
Daniel Susan E.
Publication year - 1995
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870100118
Subject(s) - corticobasal degeneration , substantia nigra , progressive supranuclear palsy , locus ceruleus , pathology , psychology , degenerative disease , neuroscience , medicine , central nervous system disease , parkinson's disease , disease
An 81‐year‐old woman died after a 3‐year history of a progressive nondementing akinetic‐rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele‐Richardson‐Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.