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Fluctuations in plasma levodopa and motor responses with liquid and tablet levodopa/carbidopa
Author(s) -
Metman L. Verhagen,
Hoff J.,
Mouradian M. M.,
Chase T. N.
Publication year - 1994
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870090416
Subject(s) - levodopa , carbidopa , placebo , crossover study , parkinson's disease , anesthesia , pharmacology , psychology , medicine , chemistry , disease , pathology , alternative medicine
To evaluate the ability of orally administered liquid levodopa/carbidopa (LD/CD) to stabilize plasma levodopa levels and reduce motor reponse fluctuations in Parkinson's disease, five patients received LD/CD hourly, as standard tablets or as an aqueous solution on two separate days in a double‐blind, placebo‐controlled, cross‐over design. Except for a slightly earlier peak plasma levodopa level, no significant advantage of the liquid formulation over tablet therapy was found. However, liquid LD/CD could be helpful in quickly resolving “off” states and by facilitating small dose adjustments that are not possible with tablets.