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Vascular chorea: Case report with pathology
Author(s) -
Bhatia Kailash P.,
Lera Gabriel,
Luthert Philip J.,
Marsden C. David
Publication year - 1994
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870090412
Subject(s) - chorea , gliosis , angiopathy , pathology , dementia , medicine , vascular dementia , cortex (anatomy) , alzheimer's disease , degenerative disease , neuroscience , disease , psychology , endocrinology , diabetes mellitus
We report a patient with long‐standing systemic hypertension who developed progressive generalized chorea and dementia beginning at 70 years of age with no family history or other features to suggest Huntington's disease. At postmortem examination, congophilic angiopathy and atherosclerosis causing neostriatal neuronal loss and gliosis were found, in addition to plaques and neurofibrillary tangles in the cortex. This case is a rare demonstration of a vascular pathology causing late onset generalized chorea in association with dementia due to Alzheimer's‐type cortical changes.