Premium
The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease
Author(s) -
Guridi J.,
Luquin M. R.,
Herrero M. T.,
Obeso J. A.
Publication year - 1993
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870080402
Subject(s) - subthalamic nucleus , globus pallidus , parkinsonism , neuroscience , parkinson's disease , glutamatergic , degenerative disease , medicine , deep brain stimulation , psychology , basal ganglia , disease , central nervous system disease , central nervous system , pathology , glutamate receptor , receptor
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.