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Reversible striatal hypermetabolism in a case of sydenham's chorea
Author(s) -
Goldman Serge,
Amrom Dina,
Szliwowski Henri B.,
Detemmerman Dominique,
Goldman Sylvie,
Bidaut Luc M.,
Stanus Etienne,
Luxen André
Publication year - 1993
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870080318
Subject(s) - putamen , hypermetabolism , caudate nucleus , chorea , striatum , subthalamic nucleus , positron emission tomography , medicine , basal ganglia , dyskinesia , endocrinology , movement disorders , neuroscience , psychology , parkinson's disease , anesthesia , dopamine , nuclear medicine , deep brain stimulation , central nervous system , disease
We studied a 10‐year‐old girl with Sydenham's chorea (SC) using positron emission tomography (PET) with fluorodeoxyglucose (FDG). Choreic movements involved the head and the left side of her body. PET showed increased glucose metabolism in the right caudate nucleus and putamen. Three months after complete recovery, striatal glucose metabolism had returned to normal in the caudate nucleus. In the right putamen, glucose metabolism had decreased compared to that in the first study but remained elevated compared to that of normal young adults. We propose that the transient striatal hypermetabolism may have been due to increased afferent inputs to the striatum as a consequence of striatal or subthalamic nucleus dysfunction.