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Visual and auditory evoked potentials in early onset parkinson's disease and their relationship to cerebrospinal fluid monoamine metabolites
Author(s) -
Muthane Uday B.,
Satishchandra P.,
Subhash M. N.
Publication year - 1993
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870080316
Subject(s) - homovanillic acid , cerebrospinal fluid , medicine , monoamine neurotransmitter , dopaminergic , endocrinology , psychology , correlation , dopamine , serotonin , receptor , geometry , mathematics
Abstract We studied visual (VEP) and brainstem auditory (BAEP) evoked potential changes in 23 patients with early onset Parkinson's disease (EOPD) to establish the nature of the changes as well as their relationship to dopaminergic (DA) and serotonergic (5‐HT) disturbances, as determined by cerebrospinal fuid levels of homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA). We also compared these parameters between the young onset (YOPD) and juvenile Parkinsonism (JP), the two subgroups of EOPD, to look for any possible differences between the two. In EOPD, the mean P 100 latency of the VEP was significantly prolonged compared to controls (p < 0.001). However, within EOPD the evoked potential parameters were not significantly different between YOPD and the JP subgroups. P 100 latency was abnormal in six patients (YOPD: 5, JP:1) (26%). Six patients (YOPD: 3, JP:3) (26%) had abnormal BAEP. A significant negative correlation (r: −0.89, p <1%) was observed between the P 100 latency and CSF HVA levels. No correlation was observed between the BAEP interpeak latencies and either CSF HVA or 5‐HIAA levels. This study suggests that VEP and BAEP abnormalities do occur in EOPD (in both YOPD and JP), and that the prolongation of P 100 latency is secondary to DA deficiency as in PD. The cause of BAEP abnormalities in EOPD. There was no correlation between the VEP or BAEP changes to either the age at onset or duration of EOPD.