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Dopamine receptors in the basal ganglia: Relevance to parkinson's disease
Author(s) -
Strange Philip G.
Publication year - 1993
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870080303
Subject(s) - basal ganglia , putamen , parkinson's disease , dopamine , neuroscience , caudate nucleus , dopamine receptor d2 , dopamine receptor , receptor , disease , biology , medicine , psychology , central nervous system
At least five receptors for dopamine (D 1 –D 5 ) have been recognised from molecular biological studies, and their pharmacological properties and brain localisations have been determined. The D 1 and D 2 subtypes are the principal subtypes in brain, and their cellular localisations in the caudate nucleus and putamen have been determined. With recent advances in the understanding of basal ganglia neuronal function, these localisation data enable insights into the mode of action of drugs used at present and in the futue to treat Parkinson's disease.