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Neuropsychological correlates of brain atrophy in Parkinson's disease: A CT‐scan study
Author(s) -
Starkstein Sergio E.,
Leiguarda Ramón
Publication year - 1993
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870080110
Subject(s) - atrophy , neuropsychology , parkinson's disease , medicine , degenerative disease , central nervous system disease , psychology , disease , pathology , cognition , neuroscience
We examined the presence of cortical or subcortical brain atrophy (as shown by CT scans) in patients with Parkinson's disease (PD) and assessed whether there were significant correlations between CT measurements and the presence of cognitive deficits. There were three main findings. First, patients with bilateral symptoms of PD showed more severe cortical and subcortical atrophy than age‐matched normal controls. Second, the presence of unilateral symptoms of PD was significantly associated with contralateral brain atrophy only in patients with right hemi‐PD. Third, there was a significant correlation between neuropsychological deficits and atrophy in specific brain areas.