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Postvaccinal parkinsonism
Author(s) -
Alves Rosana S. C.,
Barbosa Egberto R.,
Scaff Milberto
Publication year - 1992
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870070213
Subject(s) - parkinsonism , levodopa , medicine , bromocriptine , substantia nigra , pleocytosis , chorea , pediatrics , abnormality , anesthesia , surgery , pathology , disease , parkinson's disease , meningitis , psychiatry , prolactin , hormone
A 5‐year‐old boy, with a history of fever beginning 15 days after a vaccination for measles, developed a rigid‐akinetic syndrome 3 days after the fever began. A spinal tap obtained 1 week after the onset of fever showed pleocytosis with a monocellular pattern. A CT scan of the head and EEG did not disclose any abnormality. An MRI performed 3 months after the event, however, showed clear‐cut evidence of bilateral substantia nigra lesions, suggesting secondary gliosis. The response to levodopa was good, but adverse reactions appeared early. The child is now 7 years old. Bromocriptine, deprenyl, and levodopa have produced a remarkable improvement of the parkinsonian features.