Effect of ethosuximide on rest tremor in the MPTP monkey model | Zendy

GomezMancilla Baltazar | Zendy; Latulippe JeanFrançois | Zendy; Boucher René | Zendy; Bédard Paul J. | Zendy

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Effect of ethosuximide on rest tremor in the MPTP monkey model

Author(s) -

GomezMancilla Baltazar,

Latulippe JeanFrançois,

Boucher René,

Bédard Paul J.

Publication year - 1992

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.870070207

Subject(s) - ethosuximide , diltiazem , mptp , verapamil , thalamus , medicine , essential tremor , neuroscience , dopamine , calcium , psychology , dopaminergic , epilepsy , anticonvulsant

Abstract Based on the hypothesis that low‐threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the antitremor effect of the dopamine D 2 agonist LY‐171555.

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