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Effect of ethosuximide on rest tremor in the MPTP monkey model
Author(s) -
GomezMancilla Baltazar,
Latulippe JeanFrançois,
Boucher René,
Bédard Paul J.
Publication year - 1992
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870070207
Subject(s) - ethosuximide , diltiazem , mptp , verapamil , thalamus , medicine , essential tremor , neuroscience , dopamine , calcium , psychology , dopaminergic , epilepsy , anticonvulsant
Based on the hypothesis that low‐threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the antitremor effect of the dopamine D 2 agonist LY‐171555.