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Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism
Author(s) -
GomezMancilla Baltazar,
Boucher René,
Bédard Paul J.
Publication year - 1992
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870070108
Subject(s) - agonist , parkinsonism , mptp , chemistry , medicine , pharmacology , parkinson's disease , receptor , disease
The antitremor effect of the D 2 agonist LY 171555 and of the D 1 agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D 2 agonist suppressed rest tremor in a dose‐dependent fashion. The D 1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.