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Intrafamilial correlation in idiopathic torsion dystonia
Author(s) -
Fletcher N. A.,
Harding A. E.,
Marsden C. D.
Publication year - 1991
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870060407
Subject(s) - dystonia , medicine , physical medicine and rehabilitation , pediatrics , psychiatry
Abstract Age of onset and severity of idiopathic torsion dystonia (ITD) were studied in 100 British families containing 107 index cases and 79 secondary cases. Analysis of variance of these clinical features did not suggest that ITD is genetically heterogenous, and they were similar in Jewish and non‐Jewish patients. Intrafamilial correlation for age of onset was low, particularly between parents and their offspring, suggesting that the ITD phenotype may be determined in part by nongenetic factors or an allelic modifying gene.