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Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate
Author(s) -
Aziz T. Z.,
Peggs D.,
Sambrook M. A.,
Crossman A. R.
Publication year - 1991
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870060404
Subject(s) - mptp , subthalamic nucleus , parkinsonism , lesion , nucleus , neuroscience , parkinson's disease , medicine , psychology , pathology , disease , deep brain stimulation
Central to the neural mechanism of MPTP‐induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.