Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats | Zendy

Pezzoli Gianni | Zendy; Zecchinelli Anna | Zendy; Ricciardi Sante | Zendy; Burke Robert E. | Zendy; Fahn Stanley | Zendy; Scarlato Guglielmo | Zendy; Carenzi Angelo | Zendy

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Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats

Author(s) -

Pezzoli Gianni,

Zecchinelli Anna,

Ricciardi Sante,

Burke Robert E.,

Fahn Stanley,

Scarlato Guglielmo,

Carenzi Angelo

Publication year - 1991

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.870060403

Subject(s) - dopaminergic , substantia nigra , tyrosine hydroxylase , endocrinology , neurotrophic factors , medicine , parkinsonism , nigrostriatal pathway , dopamine , epidermal growth factor , glial cell line derived neurotrophic factor , receptor , disease

We assessed the effect of a 35‐day delayed intracerebroventricular (ICV) infusion of epidermal growth factor (EGF) on the survival and function of the substantia nigra (SN) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. EGF infusion for 28 days resulted in a twofold increase in the number of surviving tyrosine‐hydroxylase (TH)–positive SN neurons and a significant increase in ipsilateral striatal TH‐positive fiber staining compared to controls at 200 days following the injury. In addition, there was a persistent enhancement of behavioral recovery, as indicated by a reduction in amphetamine‐induced rotations. We conclude that EGF exerts a neurotrophic effect on the dopaminergic neurons in this experimental model of parkinsonism.

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