Premium
Mood changes and “on‐off” phenomena in Parkinson's disease
Author(s) -
Menza Matthew A.,
Sage Jacob,
Marshall Eric,
Cody Ronald,
Duvoisin Roger
Publication year - 1990
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870050210
Subject(s) - dyskinesia , parkinson's disease , mood , levodopa , depression (economics) , anxiety , psychology , dopamine , dopaminergic , disease , concomitant , psychiatry , medicine , neuroscience , economics , macroeconomics
Ten patients with idiopathic Parkinson's disease and motor fluctuations were rated for mood changes during discrete “off,” “on,” and “on with dyskinesia” periods. The Profile of Mood States and visual analogue scales were used. Significant changes in mood and anxiety were found to parallel changes in motor fluctuations. One patient rated his moods as consistently improving from the “off” state to the “on” state and finally to the “on with dyskinesia” state, a finding that is consistent with concomitant central dopaminergic changes. All other patients showed moods that improved significantly from the “off” state to the “on” state but then worsened significantly in the “on with dyskinesia” state, a finding that is consistent with the fact that patients feel worse when impaired by dyskinesias. It is suggested that these results argue for multiple etiologies of depression in Parkinson's disease. The literature on dopamine and depression in Parkinson's disease is briefly reviewed and the opportunity provided by “on‐off” phenomena to study the effect of dopamine on mood changes is discussed.