Betel nut‐induced extrapyramidal syndrome: An unusual drug interaction | Zendy

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Betel nut‐induced extrapyramidal syndrome: An unusual drug interaction

Author(s) -

Deahl Martin

Publication year - 1989

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.870040406

Subject(s) - arecoline , betel , anticholinergic , nut , medicine , anticholinergic agents , antagonism , clozapine , drug , pharmacology , traditional medicine , schizophrenia (object oriented programming) , psychiatry , muscarinic acetylcholine receptor , receptor , structural engineering , engineering

Two cases are described of chronic schizophrenic patients maintained on depot neuroleptics, who developed severe extrapyramidal symptoms following a period of heavy betel nut consumption. A mechanism for this effect is proposed based on the pharmacological antagonism of the anticholinergic agent, procyclidine, by the active alkaloid ingredient of the betel, arecoline.

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