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Betel nut‐induced extrapyramidal syndrome: An unusual drug interaction
Author(s) -
Deahl Martin
Publication year - 1989
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870040406
Subject(s) - arecoline , betel , anticholinergic , nut , medicine , anticholinergic agents , antagonism , clozapine , drug , pharmacology , traditional medicine , schizophrenia (object oriented programming) , psychiatry , muscarinic acetylcholine receptor , receptor , structural engineering , engineering
Abstract Two cases are described of chronic schizophrenic patients maintained on depot neuroleptics, who developed severe extrapyramidal symptoms following a period of heavy betel nut consumption. A mechanism for this effect is proposed based on the pharmacological antagonism of the anticholinergic agent, procyclidine, by the active alkaloid ingredient of the betel, arecoline.