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Pure akinesia due to lewy body Parkinson's disease: A case with pathology
Author(s) -
Quinn N. P.,
Luthert P.,
Honavar M.,
Marsden C. D.
Publication year - 1989
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870040112
Subject(s) - parkinson's disease , lewy body , lewy body disease , medicine , degenerative disease , pathology , disease , neuroscience , psychology , dementia with lewy bodies , dementia
Abstract The case of a patient with levodopa‐responsive pure akinesia and freezing of gait for 17 years, whose brain showed the classical changes of Lewy body Parkinson's disease at postmortem is presented. A short trial of DL‐threo–DOPS was ineffective. Intellectual function was preserved despite the presence of Lewy bodies and mild cell loss in subcortical cholinergic nuclei. Pure akinesia is likely to be a heterogeneous condition, with most cases having little or no response to levodopa therapy. However, this case demonstrates that this clinical picture may be caused by Lewy body Parkinson's disease.