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Systemic toxicity of botulinum toxin by intramuscular injection in the monkey
Author(s) -
Scott Alan B.,
Suzuki David
Publication year - 1988
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870030409
Subject(s) - toxicity , botulinum toxin , intramuscular injection , toxin , medicine , body weight , pharmacology , anesthesia , biology , microbiology and biotechnology
Botulinum toxin (Oculinum) was injected intramuscularly into eight monkeys. The LD 50 dose is estimated to be ∼39 U/kg body weight. The lowest dose that caused systemic toxicity, 33 U/kg, was close to the fatal dose range, 38–42 U/kg.
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