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Decrease of serotonin‐S 2 receptors in temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy
Author(s) -
Maloteaux J. M.,
Laterre E. C.,
Laduron P. M.,
JavoyAgid F.,
Agid Y.
Publication year - 1988
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870030310
Subject(s) - progressive supranuclear palsy , hippocampus , serotonin , receptor , parkinson's disease , temporal cortex , neuroscience , cortex (anatomy) , dementia , degenerative disease , alzheimer's disease , psychology , 5 ht receptor , cerebral cortex , medicine , disease , endocrinology , biology , central nervous system disease
The number of serotonin‐S 2 receptors was decreased in the temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy (PSP). There was no significant modification of these receptors in the frontal cortex or in the hippocampus and putamne in both diseases. The decrease in mumber of receptors in PSP was unexpected, because the cerebral cortex is thought to be spared in this disease. There was no correlation between the decrease in number of serotonin‐S 2 receptors and the degree of dementia in Parkinson's disease, suggesting that these receptors are not directly involved in the deterioration of cognitive functions.