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Pathological report of four patients presenting with cranial dystonias
Author(s) -
Gibb W. R. G.,
Lees A. J.,
Marsden C. D.
Publication year - 1988
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870030305
Subject(s) - pathological , medicine , central nervous system disease , neuroscience , physical medicine and rehabilitation , pathology , psychology , surgery
Secondary dystonias and experimental models of dystonia suggest that mechanisms responsible for primary dystonias may lie in the basal gaglia or brainstem. A histological study ahs been done in three patients with cranial dystonia (blepharospasm with oromandibular dystonia in two, blepharospasm alone in one), and one patient with craniocervical dystonia (oromandibular dystonia with retrocollis). In the patient with blepharospasm alone, an angioma, 0.5 mm in diameter, was found in the dorsal pons at the site of the central tegmental tract, confirming that some patients presenting with primary dystonias may have longstanding lesions in the brainstem. In the three other cases, the striatum, pallidum, thalamus, and brainstem were examined and cell populations in the putamen, substantia nigra, and inferior olives were compared with age‐matched controls, but no significant abnormality was found.