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Preservation of the substanitia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four‐year period
Author(s) -
Quinn Niall,
Parkes David,
Janota Ivan,
Marsden C. D.
Publication year - 1986
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870010109
Subject(s) - locus coeruleus , substantia nigra , parkinsonism , levodopa , medicine , parkinson's disease , decarboxylase inhibitor , midbrain , anesthesia , pathology , disease , central nervous system
Abstract A 72‐year‐old hypertensive man developed parkinsonism and was treated with Sinemet for 4 years but then died of a bronchial carcinoma. Necropsy revealed cerebrovascular disease and amyloid angiopathy. The substantia nigra and locus coeruleus were normal on light microscopy.