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Striatal inhomogeneities and basal ganglia function
Author(s) -
Penney John B.,
Young Anne B.
Publication year - 1986
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.870010102
Subject(s) - citation , neurology , library science , gerontology , psychology , medicine , computer science , neuroscience
It has always been something of a mystery as to why different diseases of the basal ganglia may produce completely opposite effects on movement. Thus, defective dopaminergic inhibitory input into the striatum in Parkinson’s disease causes an akinetic-rigid syndrome, while destruction of the striatum in Huntington’s disease usually causes chorea. This theoretic paradox may be resolved by more detailed examination of the exact sites of striatal damage in the two opposing conditions (1). C. D. Marsden