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An MDS Evidence‐Based Review on Treatments for Huntington's Disease
Author(s) -
Ferreira Joaquim J.,
Rodrigues Filipe B.,
Duarte Gonçalo S.,
Mestre Tiago A.,
BachoudLevi AnneCatherine,
Bentivoglio Anna Rita,
Burgunder JeanMarc,
Cardoso Francisco,
Claassen Daniel O.,
Landwehrmeyer G. Bernard,
Kulisevsky Jaime,
Nirenberg Melissa J.,
Rosser Anne,
Roth Jan,
Seppi Klaus,
Slawek Jaroslaw,
FurrStimming Erin,
Tabrizi Sarah J.,
Walker Francis O.,
Vandenberghe Wim,
Costa João,
Sampaio Cristina
Publication year - 2022
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28855
Subject(s) - medicine , apathy , tetrabenazine , chorea , huntington's disease , randomized controlled trial , psychiatry , disease , medline , clinical trial , psychological intervention , irritability , movement disorders , physical therapy , anxiety , political science , dopamine , law
Background Huntington's disease (HD) is a rare neurodegenerative disorder with protean clinical manifestations. Its management is challenging, consisting mainly of off‐label treatments. Objectives The International Parkinson and Movement Disorder Society commissioned a task force to review and evaluate the evidence of available therapies for HD gene expansion carriers. Methods We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Eligible randomized controlled trials were identified via an electronic search of the CENTRAL, MEDLINE, and EMBASE databases. All eligible trials that evaluated one or more of 33 predetermined clinical questions were included. Risk of bias was evaluated using the Cochrane Risk of Bias tool. A framework was adapted to allow for efficacy and safety conclusions to be drawn from the balance between the GRADE level of evidence and the importance of the benefit/harm of the intervention. Results Twenty‐two eligible studies involving 17 interventions were included, providing data to address 8 clinical questions. These data supported a likely effect of deutetrabenazine on motor impairment, chorea, and dystonia and of tetrabenazine on chorea. The data did not support a disease‐modifying effect for premanifest and manifest HD. There was no eligible evidence to support the use of specific treatments for depression, psychosis, irritability, apathy, or suicidality. Similarly, no evidence was eligible to support the use of physiotherapy, occupational therapy, exercise, dietary, or surgical treatments. Conclusions Data for therapeutic interventions in HD are limited and support only the use of VMAT2 inhibitors for specific motor symptoms. © 2021 International Parkinson and Movement Disorder Society