Premium
Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity
Author(s) -
Hengel Holger,
Martus Peter,
Faber Jennifer,
GarciaMoreno Hector,
Solanky Nita,
Giunti Paola,
Klockgether Thomas,
Reetz Kathrin,
Warrenburg Bart P.,
Pereira de Almeida Luís,
Santana Magda M.,
Januário Cristina,
Silva Patrick,
Thieme Andreas,
Infante Jon,
Vries Jeroen,
Lima Manuela,
Ferreira Ana F.,
Bushara Khalaf,
Jacobi Heike,
Onyike Chiadi,
Schmahmann Jeremy D.,
HübenerSchmid Jeannette,
Synofzik Matthis,
Schöls Ludger
Publication year - 2022
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28844
Subject(s) - spinocerebellar ataxia , medicine , body mass index , disease , ataxia , cohort , physical therapy , abstinence , prospective cohort study , cohort study , gerontology , psychiatry
Background Lifestyle could influence the course of hereditary ataxias, but representative data are missing. Objective The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. Methods In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. Results Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. Conclusion Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society