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Longitudinal Change in Quality of Life in Neurological Disorders Measures Over 3 Years in Patients with Early Parkinson's Disease
Author(s) -
Marras Connie,
Mills Kelly A.,
Eberly Shirley,
Oakes David,
Chou Kelvin L.,
Halverson Matthew,
Parashos Sotirios A.,
Tarolli Christopher G.,
Lai JinShei,
Nowinsky Cindy J.,
Suchowersky Oksana,
Farbman Eric S.,
Shulman Lisa M.,
Simuni Tanya
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28641
Subject(s) - quality of life (healthcare) , clinical trial , parkinson's disease , disease , movement disorders , physical therapy , medicine , cohort , cognition , physical medicine and rehabilitation , construct validity , activities of daily living , pediatrics , psychology , psychometrics , psychiatry , clinical psychology , nursing
Background The Quality of Life in Neurological Disorders (Neuro‐QoL) is a publicly available health‐related quality‐of‐life measurement system. Objective The aim of this study was to evaluate the utility of Neuro‐QoL item banks as outcome measures for clinical trials in Parkinson's disease. Methods An analysis of Neuro‐QoL responsiveness to change and construct validity was performed in a multicenter clinical trial cohort. Results Among 310 participants over 3 years, changes in five of eight Neuro‐QoL domains were significant ( P < 0.05) but very modest. The largest effect sizes were seen in the cognition and mobility domains (0.35–0.39). The largest effect size for change over the year in which levodopa was initiated was −0.19 for lower extremity function–mobility. For a similarly designed clinical trial, estimated sample size required to demonstrate a 50% reduction in worsening ranged from 420 to more than 1000 participants per group. Conclusions More sensitive tools will be required to serve as an outcome measure in early Parkinson's disease. © 2021 International Parkinson and Movement Disorder Society