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Intronic Haplotypes in the GBA Gene Do Not Predict Age at Diagnosis of Parkinson's Disease
Author(s) -
Toffoli Marco,
Higgins Abigail,
Lee Chiao,
Koletsi Sofia,
Chen Xiao,
Eberle Michael,
Sedlazeck Fritz J.,
Mullin Stephen,
Proukakis Christos,
Schapira Anthony H.V.
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28616
Subject(s) - haplotype , cohort , parkinson's disease , parkinsonism , disease , lrrk2 , movement disorders , medicine , cohort study , genetics , oncology , gene , biology , genotype
ABSTRACT Background GBA mutations are a common risk factor for Parkinson's disease (PD). A recent study has suggested that GBA haplotypes, identified by intronic variants, can affect age at diagnosis of PD. Objectives In this study, we assess this hypothesis using long reads across a large cohort and the publicly available Accelerating Medicines Partnership–Parkinson's Disease (AMP‐PD) cohort. Methods We recruited a PD cohort through the Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease study (RAPSODI) and sequenced GBA using Oxford Nanopore technology. Genetic and clinical data on the full AMP‐PD cohort were obtained from the online portal of the consortium. Results A total of 1417 participants were analyzed. There was no significant difference in age at PD diagnosis between the two main haplotypes of the GBA gene. Conclusions GBA haplotypes do not affect age at diagnosis of PD in the two independent cohorts studied. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society