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Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Author(s) -
Burtscher Johannes,
Syed Muhammed Muazzam Kamil,
Lashuel Hilal A.,
Millet Grégoire P.
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28544
Subject(s) - neuroprotection , hypoxia (environmental) , parkinson's disease , neuroscience , disease , medicine , pathogenesis , degenerative disease , psychology , pathology , oxygen , chemistry , organic chemistry
Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how neuroprotective effects can be induced by hypoxia conditioning and how related approaches have the potential to be harnessed as therapeutic strategies in Parkinson's disease. © 2021 International Parkinson and Movement Disorder Society