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Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease
Author(s) -
EstevezFraga Carlos,
Scahill Rachael I.,
Durr Alexandra,
Leavitt Blair R.,
Roos Raymund A.C.,
Langbehn Douglas R.,
Rees Geraint,
Gregory Sarah,
Tabrizi Sarah J.
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28489
Subject(s) - fractional anisotropy , white matter , huntington's disease , psychology , atrophy , medicine , voxel based morphometry , disease , magnetic resonance imaging , neuroscience , radiology
Background The composite Unified Huntington's Disease Rating Scale (cUHDRS) is a multidimensional measure of progression in Huntington's disease (HD) being used as a primary outcome in clinical trials investigating potentially disease‐modifying huntingtin‐lowering therapies. Objective Evaluating volumetric and structural connectivity correlates of the cUHDRS. Methods One hundred and nineteen premanifest and 119 early‐HD participants were included. Gray and white matter (WM) volumes were correlated with cUHDRS cross‐sectionally and longitudinally using voxel‐based morphometry. Correlations between baseline fractional anisotropy (FA); mean, radial, and axial diffusivity; and baseline cUHDRS were examined using tract‐based spatial statistics. Results Worse performance in the cUHDRS over time correlated with longitudinal volume decreases in the occipito‐parietal cortex and centrum semiovale, whereas lower baseline scores correlated with decreased volume in the basal ganglia and surrounding WM. Lower cUHDRS scores were also associated with reduced FA and increased diffusivity at baseline. Conclusion The cUHDRS correlates with imaging biomarkers and tracks atrophy progression in HD supporting its biological relevance. © 2021 International Parkinson and Movement Disorder Society