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Inflammation in Experimental Models of α ‐Synucleinopathies
Author(s) -
Harms Ashley S.,
Kordower Jeffrey H.,
Sette Alessandro,
Lindestam Arlehamn Cecilia S.,
Sulzer David,
Mach Robert H.
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28264
Subject(s) - synucleinopathies , neuroinflammation , neuroscience , parkinson's disease , disease , atrophy , inflammation , animal model , medicine , central nervous system , psychology , alpha synuclein , pathology , immunology , endocrinology
Neuroinflammation has long been associated with central nervous system pathology in α‐synucleinopathy disorders including Parkinson's disease and multiple system atrophy. In the past decade, research‐focused efforts in preclinical and experimental models have rallied around this idea, and considerable effort has been made to delineate critical neuroinflammatory processes. In this article, we discuss challenges in preclinical research, notably the use of animal models to recapitulate and dissect disease phenotypes as well as the need for more sensitive, reliable radiotracers to detect on‐target efficacy of immunomodulatory treatments in both human Parkinson's disease as well as preclinical models. © 2020 International Parkinson and Movement Disorder Society