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Clinical and Demographic Characteristics of Upper Limb Dystonia
Author(s) -
Norris Scott A.,
Jinnah Hyder A.,
Klein Christine,
Jankovic Joseph,
Berman Brian D.,
Roze Emmanuel,
Mahajan Abhimanyu,
Espay Alberto J.,
Murthy Avinash V.,
Fung Victor S.C.,
LeDoux Mark S.,
Chang Florence C.F.,
Vidailhet Marie,
Testa Claudia,
Barbano Richard,
Malaty Irene A.,
Bäumer Tobias,
Loens Sebastian,
Wright Laura J.,
Perlmutter Joel S.
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28223
Subject(s) - dystonia , focal dystonia , upper limb , physical medicine and rehabilitation , medicine , age of onset , movement disorders , lower limb , psychology , surgery , disease , psychiatry , pathology
Background Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single‐site studies. Objective The objective of this study was to characterize demographic and clinical characteristics of upper limb dystonia from the Dystonia Coalition data set, a large, international, multicenter resource. Methods We evaluated clinical and demographic characteristics of 367 participants with upper limb dystonia from onset, comparing across subcategories of focal (with and without dystonia spread) versus nonfocal onset. Results Focal onset occurred in 80%; 67% remained focal without spread. Task specificity was most frequent in this subgroup, most often writer's cramp and affecting the dominant limb (83%). Focal onset with spread was more frequent in young onset (<21 years). Focal onset occurred equally in women and men; nonfocal onset affected women disproportionately. Conclusions Upper limb dystonia distribution, focality, and task specificity relate to onset age and likelihood of regional spread. Observations may inform clinical counseling and design, execution, and interpretation of future studies. © 2020 International Parkinson and Movement Disorder Society