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The Parkinson's Disease Genome‐Wide Association Study Locus Browser
Author(s) -
Grenn Francis P.,
Kim Jonggeol J.,
Makarious Mary B.,
Iwaki Hirotaka,
Illarionova Anastasia,
Brolin Kajsa,
Kluss Jillian H.,
SchumacherSchuh Artur F.,
Leonard Hampton,
Faghri Faraz,
Billingsley Kimberley,
Krohn Lynne,
Hall Ashley,
DiezFairen Monica,
Periñán Maria Teresa,
Foo Jia Nee,
Sandor Cynthia,
Webber Caleb,
Fiske Brian K.,
Gibbs J. Raphael,
Nalls Mike A.,
Singleton Andrew B.,
BandresCiga Sara,
Reed Xylena,
Blauwendraat Cornelis
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28197
Subject(s) - genome wide association study , genome , locus (genetics) , genetic association , genomics , disease , genetics , computational biology , gene , biology , bioinformatics , medicine , single nucleotide polymorphism , genotype
Parkinson's disease (PD) is a neurodegenerative disease with an often complex component identifiable by genome-wide association studies. The most recent large-scale PD genome-wide association studies have identified more than 90 independent risk variants for PD risk and progression across more than 80 genomic regions. One major challenge in current genomics is the identification of the causal gene(s) and variant(s) at each genome-wide association study locus. The objective of the current study was to create a tool that would display data for relevant PD risk loci and provide guidance with the prioritization of causal genes and potential mechanisms at each locus.