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A Pooled Analysis From Phase 2b and 3 Studies in Japan of Istradefylline in Parkinson's Disease
Author(s) -
Hattori Nobutaka,
Kitabayashi Hiroki,
Kanda Tomoyuki,
Nomura Takanobu,
Toyama Keizo,
Mori Akihisa
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28095
Subject(s) - medicine , parkinson's disease , logistic regression , motor function , physical therapy , physical medicine and rehabilitation , disease
Abstract Background Characterization of patient factors associated with istradefylline efficacy may facilitate personally optimized treatment. Objectives We aimed to examine which patient factors are associated with favorable istradefylline treatment outcomes in PD patients with motor complications. Methods We performed a pooled analysis of data from two identical phase 2b and 3 Japanese studies of istradefylline. Logistic regression models were used to assess the association of 12 patient characteristics with favorable outcomes. Results Off time reduction and increased good on time with istradefylline provided a significantly favorable response in patients aged ≥65 years. Off time reduction was more favorable in patients with ≥8‐hour daily off time at baseline. Improvement in UPDRS Part III was favorable in patients with UPDRS Part III baseline score ≥ 20. Conclusions Several patient factors influenced the effect of istradefylline on motor fluctuations, motor function, activities of daily living, and clinical impression. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.