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Magnetic Susceptibility Associates With Dopaminergic Deficits and Cognition in Parkinson's Disease
Author(s) -
Uchida Yuto,
Kan Hirohito,
Sakurai Keita,
Inui Shohei,
Kobayashi Susumu,
Akagawa Yoshihiro,
Shibuya Kazuyoshi,
Ueki Yoshino,
Matsukawa Noriyuki
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28077
Subject(s) - putamen , dopamine transporter , substantia nigra , caudate nucleus , striatum , dopaminergic , psychology , parkinson's disease , dopamine , quantitative susceptibility mapping , nucleus accumbens , neuroscience , medicine , magnetic resonance imaging , endocrinology , disease , radiology
Objective The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality and their associations with behavioral and cognitive impairments in patients with Parkinson's disease (PD). Methods For this case‐control study, we enrolled 41 patients with PD and 20 age‐matched healthy controls. All participants underwent global physical and cognitive assessments, 3‐Tesla brain magnetic resonance imaging including quantitative susceptibility mapping (QSM; iron deposition measure), and 123 I‐N‐v‐fluoropropyl‐2b‐carbomethoxy‐3b‐(4‐iodophenyl) nortropane single‐photon emission computed tomography (dopamine transporter measure). We subdivided the striatum into the putamen, caudate nucleus, and nucleus accumbens and measured the nigrostriatal QSM values and dopamine transporter–specific binding ratios using an atlas‐based approach. Results The patients with PD had higher QSM values in the substantia nigra and subdivisions of the striatum than did the healthy controls. The striatal dopamine transporter–specific binding ratios were not correlated with the QSM values of the substantia nigra but were inversely correlated with those of the striatum (putamen, r = −0.478, P = 0.009; caudate nucleus, r = −0.462, P = 0.011). The QSM values of the putamen were positively correlated with motor parkinsonism scores (Movement Disorder Society Unified Parkinson's Disease Rating Scale, r = 0.505, P = 0.003), and those of the caudate nucleus were negatively correlated with cognitive impairment scores (Montreal Cognitive Assessment, r = −0.525, P < 0.001). Conclusions This study showed that striatal iron accumulations were correlated with dopaminergic deficits and neurophysiological signs in patients with PD, highlighting the potential of QSM as an auxiliary biomarker for parkinsonism and cognitive dysfunction. © 2020 International Parkinson and Movement Disorder Society